Verorab Dosage/Direction for Use

vaccine, rabies


Sanofi Pasteur


Full Prescribing Info
Dosage/Direction for Use
Always use this medicine exactly as the doctor or pharmacist has told to. Check with the doctor or pharmacist if the patient is not sure. One dose consists in the administration of 0.5 mL of vaccine via the intramuscular route.
Pre-exposure vaccination: Three doses of 0.5 mL of VERORAB are administered at D0, D7 and D28 for primary vaccination. The dose scheduled at D28 can be administered at D21.
Booster doses and regular serological tests, to assess the subjects' seroconversion status, are recommended. The frequency of booster doses and serological tests is indicated in Table 1.
Each booster dose consists in the administration of one dose of 0.5 mL. (See Table 1.)

Click on icon to see table/diagram/image

For immunodeficient subjects, a serological test should be performed 2 to 4 weeks after vaccination. If the test result shows antibody titers strictly below 0.5 IU/mL, an additional injection is justified.
Post-exposure vaccination: Post-exposure treatment includes local non-specific treatment of the wound, vaccination and passive immunisation with rabies immunoglobulins. The treatment should be adapted to the nature of the contact or of the wound (see Table 2), the condition of the animal (see Table 3) and the patient's rabies vaccination status.
First aid: local treatment of the wound: Local treatment of all bites and scratches is very important and must be performed immediately.
First aid recommendations include immediate flushing out of the wound for at least 15 minutes with water and soap, detergent, povidone iodine or any other substance with a proven destructive action on the rabies virus. If no soap or antiviral agents are available, the wound should be extensively flushed out with water.
If necessary, the treatment can be supplemented by the administration of a tetanus treatment and an antibiotherapy in order to prevent the development of infections other than rabies.
Vaccination: Post-exposure vaccination must be performed under medical supervision, only in a rabies centre and as soon as possible following exposure. (See Tables 2 and 3.)

Click on icon to see table/diagram/image

Click on icon to see table/diagram/image

Vaccination of non-immunised subjects (subjects who did not receive pre-exposure vaccination): Essen regimen.
Five doses of 0.5 mL of VERORAB are administered at D0, D3, D7, D14 and D28.
Zagreb regimen (schedule 2-1-1).
Administration of four doses of 0.5 mL of VERORAB: one dose administered in the right deltoid region and one dose administered in the left deltoid region at D0, then one dose administered in the deltoid region at D7 and D21.
Whatever the regimen used, vaccination must not be discontinued unless made possible by the animal's health status (see Table 3).
Whatever the regimen used, rabies immunoglobulins should be administered at D0 concomitantly with the vaccine, in case of category III exposure (WHO classification, see Table 2). The rabies immunoglobulins posology is as follows: Human rabies immunoglobulins 20 IU/kg of body weight, Equine rabies immunoglobulins 40 IU/kg of body weight.
For more information, please see the package leaflet of the rabies immunoglobulins used.
When possible, the vaccine should be administered contra-laterally to the immunoglobulins administration sites.
For immunodeficient subjects, in the case of Category II exposure (WHO Classification, see Table 2), rabies immunoglobulins should also be administered concomitantly with the vaccine.
Vaccination of subjects already immunised (full pre-exposure vaccination confirmed): If pre-exposure vaccination was perfomed less than 5 years before (cell culture rabies vaccine): two booster doses are administered at DO and D3. Rabies immunoglobulins are not necessary.
This does not apply to immunodeficient subjects.
If pre-exposure vaccination was perfomed more than 5 years before, if it is incomplete or in case of doubt, the subject's vaccination status is not considered as complete and a full post-exposure treatment should be started (see Vaccination of non-immunised subjects previously).
If the patient is immunodeficient, a full post-exposure treatment should also be started (see Vaccination of non-immunised subjects previously).
Use in children: VERORAB can be administered to children and to adults using the same posology.
Method of administration: The vaccine is administered by the intramuscular route, generally in the anterolateral region of the thigh muscle until the age of 12 months and in the deltoid muscle after this age.
If the Zagreb regimen is used, one dose should be administered in each deltoid muscle (left and right) in adults at D0, then one dose at D7 and D21.
VERORAB must not be injected in the buttocks region.
The vaccine must not be injected via the intravascular route.
If the patient has any further questions on the use of this medicine, ask the doctor or pharmacist or nurse.
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