Bell-Kenz Pharma


Euro Generics
Concise Prescribing Info
Amlodipine besilate 5 mg, losartan K 50 mg
Mild to moderate HTN in case of inadequate control of monotherapy.
Dosage/Direction for Use
May be taken with or without food.
Hypersensitivity to amlodipine or dihydropyridine derivatives & losartan, other angiotensin receptor blockers or dihydropyridine Ca channel antagonist. History of angioedema. Losartan: Concomitant use w/ aliskiren in patients w/ DM or renal impairment (GFR <60 mL/min/1.73 m2). Severe hepatic impairment. Pregnancy (2nd & 3rd trimester). Amlodipine: Severe hypotension, shock (including cardiogenic shock), obstruction of the outflow tract of the left ventricle (eg, high grade aortic stenosis), haemodynamically unstable heart failure after acute MI.
Special Precautions
Patients w/ intravascular vol-depletion (eg, those treated w/ diuretics), severe obstructive CAD, CHF; electrolyte imbalance; whose renal function depend on the activity of RAAS. Severe renal disease, unilateral or bilateral renal artery stenosis; hepatic impairment. Discontinue during pregnancy & lactation. Childn.
Adverse Reactions
Diarrhea, dyspepsia, muscle cramp, myalgia, back & leg pain, dizziness, insomnia, nasal congestion, cough, upper resp tract infection, sinus disorder, sinusitis, edema, flushing, palpitation, fatigue, headache, somnolence, abdominal pain.
Drug Interactions
Losartan: Decreased conc w/ rifampin. Decreased active metabolite conc & increased conc w/ fluconazole. Increased serum K w/ K-sparing diuretics, K supplements or salt substitutes containing K. May reduce excretion of lithium. May diminish antihypertensive effect w/ NSAIDs including selective COX-2 inhibitors.
ATC Classification
C09DB06 - losartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
Veztenor FC tab
30's (P21.5/film-coated tab, P645/box)
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