Each 5 mL ampoule contains: Ascorbic acid 500 mg.
Pharmacology: Pharmacokinetics: Vitamin C is readily absorbed from the gastrointestinal tract and is widely distributed in the body tissues. Plasma concentrations of Vitamin C rise as the dose of about 90 to 150 mg daily. Body stores of Vitamin C in health are about 1.5 g although more may be stored at intakes above 200 mg daily. The concentration is higher in leucocytes and platelets than in erythrocytes and plasma. In deficiency states the concentration in leucocytes declines later at a slower rate and has been considered to be better criterion for the evaluation of deficiency than the concentration in plasma.
Distribution: Widely distributed in body tissues with about 25% bound to plasma proteins. Large amounts are present in leucocytes and platelets. Ascorbic acid crosses the placenta.
Metabolism: Readily oxidized to dehydroascorbic acid where some is metabolised to oxalic acid and the inactive ascorbate-2-sulphate. Metabolic turnover appears to be greater in females than males.
Excretion: Large doses are rapidly excreted in the urine when in excess of the requirements of the body and after an intravenous dose, about 40% is excreted in 8 hours, which is increased to about 70% after tissue saturation. The amount of unchanged drug is dose dependent; in women the excretion of ascorbic acid appears to vary with the stage of the menstrual cycle and it is decreased when taking oral contraceptives.
Used in the prevention of Scurvy.
Ascorbic acid (vitamin c) a water-soluble vitamin, is essential for the synthetic of collagen and intercellular material.
Vitamin C deficiency develops when the dietary intake is inadequate. It is rare in adults, but may occur in infants, alcoholics, or the elderly. Deficiency leads to the development of a well-defined syndrome known as scurvy. This is characterized by capillary fragility, bleeding (especially from small blood vessels and the gums.), normocytic or macrocytic anaemic, cartilage and bone lesions, and slow healings of wounds. Vitamin C is used in the treatment and prevention of deficiency. It completely reserves symptoms of deficiency. It is usually given orally, the preferred route, as ascorbic acid, and has been given to children in the form of a suitable fruit juice such as orange juice or as black currant or rose hip syrups.
Excess amounts of vitamin C can be dangerous.
The ampoule should be inspected for signs of discolouration or particulate matter before administration of the injection.
Seek immediate emergency medical attention if the patient suffers an allergic reaction. Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing.
This medication may not be safe for all patients. Before the patient begins using it always disclose the following to a doctor: If pregnant or breastfeeding; If suffering from any allergies; If suffering from any other health conditions or illnesses; If using any other medicine (including all non-prescription); If using any supplements, vitamins, or herbal products of any kind.
Some patients treated with (Vitamin C) may experience sores at the injection site. If the injection is given too rapidly, dizziness may occur. Other possible side effects include: Nausea, Diarrhea, Headache, Flushing, Ingestion or cramps in the stomach.
Store at temperature not exceeding 30°C. Protect from light.
A11GA01 - ascorbic acid (vit C) ; Belongs to the class of ascorbic acid (vitamin C). Used as dietary supplements.
Soln for inj (amp) 100 mg/mL x 5 mL x 10's.