Body as a Whole:
Very common: Withdrawal symptoms, fatigue. Common: Asthenia, fever, flu syndrome, pain, back pain. Uncommon: Neck pain, pelvic pain, malaise, chills, face edema, moniliasis. Rare: Hypothermia. Unknown: Neonatal withdrawal.
Common: Tachycardia, palpitations, postural hypotension. Uncommon: Bradycardia, syncope, vasodilation, cerebral ischemia, irregular pulse, cerebrovascular accident, deep thrombophlebitis, hypotension, prolonged QT interval T wave abnormality, bundle branch block, T-wave inversion. Rare: VTE, angina pectoris, atrial fibrillation, congestive heart failure, thrombophlebitis, AV block first degree, ST elevated, T-wave flattening, ST abnormality, increased QRS duration. Unknown: Cardiomyopathy, myocarditis.
Central and Autonomic Nervous System:
Very Common: Dizziness, somnolence, EPS (i.e., akathisia, tremor, hypokinesia, hypertonia, restlessness, psychomotor hyperactivity, muscle rigidity, dyskinesia), headache, agitation. Common: Irritability, dysarthria, abnormal dreams and nightmares, suicide attempt, sedation, lethargy, anxiety, paresthesia, hypersomnia. Uncommon: Seizures, restless leg syndrome, abnormal thinking, tardive dyskinesia, involuntary movements, confusion, amnesia, psychosis, hallucinations, incoordination, paranoid reaction, abnormal gait, myoclonus, delusions, manic reaction, apathy, ataxia, depersonalization, stupor, bruxism, catatonic reaction, hemiplegia. Rare: NMS, somnambulism (and other related events), aphasia, buccoglossal syndrome, choreoathetosis, delirium, emotional lability, euphoria, neuralgia, stuttering, subdural hematoma.
Dermatologic and Sensitivity Reactions:
Common: Rash. Uncommon: Hypersensitivity, photosensitivity reaction, pruritus, acne, eczema, contact dermatitis, maculopapular rash, seborrhea, skin ulcer. Very Rare: Anaphylactic reaction, Stevens-Johnson syndrome. Unknown: Toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, psoriasis, skin discoloration.
Endocrine and Metabolic:
Very Common: Elevations in non-fasting serum triglyceride levels, elevations in total cholesterol (predominantly LDL cholesterol), decreases in HDL cholesterol, weight gain. Common: Peripheral edema, hyperglycemia, elevations in serum prolactin, hypothyroidism, hyperthyroidism, increased appetite. Uncommon: Angioedema, hyponatremia, diabetes mellitus, increased libido, weight loss, increased alkaline phosphatase, hyperlipemia, alcohol intolerance, dehydration, hypoglycemia. Rare: Increased creatinine, priapism, galactorrhea, metabolic syndrome, glycosuria, gout, hand edema, hypokalemia, water intoxication, decreased libido.
Very common: Dry mouth. Common: Constipation, dyspepsia, vomiting, abdominal pain, anorexia. Uncommon: Dysphagia, increased salivation, gingivitis, flatulence, gastroenteritis, gastritis, hemorrhoids, stomatitis, thirst, tooth caries, fecal incontinence, gastroesophageal reflux, gum hemorrhage, mouth ulceration, rectal hemorrhage, tongue edema. Rare: Enlarged abdomen, pancreatitis, glossitis, hematemesis, intestinal obstruction, melena, esophageal dysmotility, aspiration.
Uncommon: Urinary retention, sexual dysfunction, dysmenorrhea, vaginitis, urinary incontinence, metrorrhagia, impotence, dysuria, vaginal moniliasis, abnormal ejaculation, cystitis, urinary frequency, amenorrhea, female lactation, leukorrhea, vaginal hemorrhage, vulvovaginitis, orchitis. Rare: Gynecomastia, nocturia, polyuria, acute kidney failure. Very Rare: Syndrome of inappropriate antidiuretic hormone secretion (SIADH), breast swelling, menstrual disorder.
Very Common: Decreased hemoglobin. Common: Leukopenia, eosinophilia, neutropenia. Uncommon: Thrombocytopenia, anemia, leukocytosis, ecchymosis, hypochromic anemia, lymphadenopathy, cyanosis. Rare: Agranulocytosis, hemolysis.
Common: Elevations in serum transaminases such as alanine transaminase (ALT) and aspartate aminotransferase (AST), elevations in gamma-glutamyl transpeptidase (GGT) levels. Rare: Jaundice, hepatitis.
Uncommon: Pathological fracture, myasthenia, twitching, arthralgia, arthritis, leg cramps, bone pain. Very Rare: Rhabdomyolysis.
Common: Increased cough, dyspnea, pharyngitis, nasal congestion. Uncommon: Rhinitis, pneumonia, epistaxis, asthma. Rare: Hiccup, hyperventilation.
Common: Blurred vision, amblyopia, conjunctivitis, abnormal vision, dry eyes, blepharitis, eye pain, tinnitus, ear pain. Uncommon: Vertigo, abnormality of accommodation, glaucoma, deafness.