Monotherapy Initially 100 mg bid, increased to 150 mg bid after 1 wk. May be further increased at wkly interval by 50 mg bid (100 mg/day) depending on response & tolerability. Max recommended daily maintenance dose: 200 mg bid (400 mg/day).
Conversion to monotherapy Initially 100 mg bid, increased to 150 mg bid after 1 wk. May be further increased by 50 mg bid (400 mg/day).
Adjunctive therapy Initially 50 mg bid, increased to an initial therapeutic dose of 100 mg bid after 1 wk. May be further increased by 50 mg bid (100 mg/day). Max dose: 400 mg daily (200 mg bid).
Initiation w/ a loading dose Initiated w/ a single loading dose of 200 mg, followed approx 12 hr later by a 100 mg bid (200 mg/day) maintenance dose, can be further increase by 50 mg bid wkly. Max: 400 mg.
Severe renal impairment (CrCl ≤30 mL/min) & end-stage renal disease, hepatic impairment Max maintenance dose: 300 mg/day.
Patient requiring hemodialysis Supplement of up to 50% of the divided daily dose directly after the end of hemodialysis.
Sign Out
