Cytotoxic-Induced Neutropenia: Adults and Children: Preferably by SC injection or by IV infusion (over 30 min). 500,000 units/kg daily, started not <24 hrs after cytotoxic chemotherapy, continued until neutrophil count is in normal range, usually for up to 14 days (up to 38 days in acute myeloid leukemia).
Myeloablative Therapy Followed by Bone Marrow Transplantation: 1,000,000 units/kg daily by IV infusion over 30 min or over 24 hrs or by SC infusion over 24 hrs, started not less than 24 hrs following cytotoxic chemotherapy (and within 24 hrs of bone marrow infusion), then adjusted according to absolute neutrophil count.
Mobilization of Peripheral Blood Progenitor Cells for Autologous Infusion: Monotherapy: 1,000,000 units/kg daily for 5-7 days by SC injection or infusion over 24 hrs. Used by following adjunct to myelosuppressive chemotherapy: 500,000 units/kg daily by SC injection (to improve yield), started on the day after completion of chemotherapy and continued until neutrophil count is in normal range.
Mobilization of Peripheral Blood Progenitor Cells in Normal Donors for Allogeneic Infusion: Adults <60 years and Adolescents >16 years: 1,000,000 units/kg daily for 4-5 days by SC injection.
Severe Chronic Neutropenia: Adults and Children: Severe Congenital Neutropenia: Initially, 1.2 million units/kg daily in single or divided doses. Idiopathic or Cyclic Neutropenia: Initially, 500,000 units/kg daily. Doses given by SC injection and adjusted according to response.
Persistent Neutropenia in HIV Infection: Initially, 100,000 units/kg daily by SC injection, increased as necessary until absolute neutrophil count is in normal range. Maximum Dose: Usually, 400,000 units/kg daily, then adjusted to maintain absolute neutrophil count in normal range.