Xanor/Xanor XR

Xanor/Xanor XR

alprazolam

Manufacturer:

Sanico NV/Pfizer Italia

Distributor:

PF OFG
Concise Prescribing Info
Contents
Alprazolam
Indications/Uses
Anxiety, depression, mixed anxiety-depression, or depression associated w/ other functional or organic disease, panic disorders.
Dosage/Direction for Use
Xanor Individualized dosage. Anxiety 0.75-1.5 mg daily in divided doses. Usual dose range: 0.5-4 mg daily in divided doses. Depression 1.5 mg daily in divided doses. Usual dose range: 1.5-4.5 mg daily in divided doses. Panic disorders 0.5-1 mg at bedtime or 0.5 mg tid. Adjust dose in increments of ≤1 mg/day every 3-4 days. Elderly 0.5-0.75 mg daily in divided doses. Usual dose range: 0.5-0.75 mg/day in divided doses, may be gradually increased if needed & tolerated. Xanor XR Anxiety 1 mg daily in 1 or 2 doses. Usual dose range: 0.5-4 mg daily in 1 or 2 doses. Depression 1 mg daily in 1 or 2 doses. Usual dose range: 0.5-4.5 mg daily in 1 or 2 doses. Panic disorders 0.5-1 mg at bedtime or 0.5 mg bid. Adjust dose in increments of ≤1 mg/day every 3-4 days. Elderly 0.5-1 mg daily in 1 or 2 doses. Usual dose range: 0.5-1 mg/day, may be gradually increased if needed & tolerated.
Administration
May be taken with or without food: Side effects eg, sleepiness/drowsiness may be reduced if taken immediately after meals. Xanor XR Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity to benzodiazepines, alprazolam.
Special Precautions
Habituation & emotional/physical dependence in high-doses & long-term use; patients w/ history of alcoholism or drug abuse. W/drawal symptoms occurred following rapid decrease or abrupt discontinuation. Panic disorders, suicide among untreated patients. Severely depressed or suicidal patients. Episodes of hypomania & mania. Not established in certain types of depression. May affect ability to drive & use machines. Impaired renal or hepatic function. Pregnancy & lactation. Childn <18 yr.
Adverse Reactions
Depression; sedation, somnolence, ataxia, memory impairment, dysarthria, dizziness, headache; constipation, dry mouth; fatigue, irritability. Decreased appetite; confusional state, disorientation, decreased libido, anxiety, insomnia, nervousness, increased libido; balance disorder, abnormal coordination, disturbance in attention, hypersomnia, lethargy, tremor; blurred vision; nausea; dermatitis; sexual dysfunction; decreased/increased wt.
Drug Interactions
Additive CNS depressant effect w/ alcohol or other drugs producing CNS depression. May increase conc & enhance activity w/ compd which inhibit certain hepatic enzymes (particularly cytochrome P4503A4). Clearance impairment, prolonged elimination t1/2 & enhanced clinical effects w/ low dose of ritonavir. Increased digoxin conc. Ketoconazole, itraconazole or other azole-type antifungals; nefazodone, fluvoxamine & cimetidine; fluoxetine, propoxyphene, OCs, diltiazem or macrolides (eg, erythromycin & troleandomycin).
MIMS Class
Anxiolytics
ATC Classification
N05BA12 - alprazolam ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
Presentation/Packing
Form
Xanor XR CR tab 1 mg
Packing/Price
100's (P4,224.49/box)
Form
Xanor XR CR tab 500 mcg
Packing/Price
100's (P2,688.59/box)
Form
Xanor tab 1 mg
Packing/Price
100's (P5,050.95/box)
Form
Xanor tab 250 mcg
Packing/Price
100's (P2,043.55/box)
Form
Xanor tab 500 mcg
Packing/Price
100's (P2,945.06/box)
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