Xet 20

Xet 20 Adverse Reactions

paroxetine

Manufacturer:

Cadila Healthcare

Distributor:

Metro Drug

Marketer:

Zydus Healthcare Phils
Full Prescribing Info
Adverse Reactions
The most commonly observed adverse effects from the use of Paroxetine were: asthenia, constipation, decreased appetite, diarrhea, dizziness, dry mouth, insomnia, male sexual dysfunction, nausea, somnolence, sweating and tremor.
The following adverse effects have been reported rarely: dizziness, rash, acute glaucoma, urinary retention, peripheral and facial edema, sinus tachycardia, thrombocytopenia, serotonergic syndrome (symptoms may include agitation, confusion, diaphoresis, hallucinations, hyperreflexia, myoclonus, shivering, tachycardia and tremor), symptoms suggestive of hyperprolactinaemia/galactorrhoea and hyponatraemia (predominantly in the elderly).
Elevation of hepatic enzymes has been reported. Serious liver abnormalities have been reported rarely. If there is a prolonged elevation on liver function test, discontinuation of treatment with Paroxetine should be considered.
Blood & lymphatic system disorders: Uncommon: abnormal bleeding, predominantly of the skin and mucous membranes, including purpura, epistaxis, haematomas, vaginal bleeding and gastrointestinal bleeding.
Immune system disorders: Very rare: allergic reactions (including urticaria and angioedema).
Endocrine disorders: Very rare: syndrome of inappropriate anti-diuretic hormone secretion (SIADH).
Metabolism & nutrition disorders: Common: decreased appetite.
Rare: hyponatraemia.
Hyponatraemia has been reported predominantly in elderly patients and is sometimes due to syndrome of inappropriate anti-diuretic hormone secretion (SIADH).
Psychiatric disorders: Common: somnolence, insomnia, agitation.
Uncommon: confusion, hallucinations.
Rare: manic reactions.
Nervous system disorders: Common: dizziness, tremor.
Uncommon: extrapyramidal disorders.
Rare: convulsions, akathisia.
Very rare: serotonin syndrome (symptoms may include agitation, confusion, diaphoresis, hallucinations, hyperreflexia, myoclonus, shivering tachycardia and tremor).
Reports of extrapyramidal disorders including oro-facial dystonia have been received in patients sometimes with underlying movement disorders or who were using neuroleptic medication.
Eye disorders: Common: blurred vision.
Very rare: acute glaucoma.
Cardiac disorders: Uncommon: sinus tachycardia
Vascular disorders: Uncommon: transient increases or decreases in blood pressure.
Transient increases or decreases of blood pressure have been reported following treatment with Paroxetine, usually in patients with pre-existing hypertension or anxiety.
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