Xyclomed Drug Interactions



Korea United Pharma


Full Prescribing Info
Drug Interactions
Barbiturates: The rate of metabolism and the leukopenic activity of cyclophosphamide reportedly are increased by chronic administration of high doses of phenobarbital.
The patients should be alerted for possible combined drug actions, desirable or undesirable, involving cyclophosphamide even though cyclophosphamide has been used successfully concurrently with other drugs.
In one administration of pentostatin to a patient with cyclophosphamide therapy, confusion, dyspnea, hypotension, pulmonary edema developed and death of the patients has been reported. In animal (mouse) studies, concomitant administration with pentostatin (about 10 times of clinical dose), cyclophosphamide (around LD50) or ephosphamide (around LD50) has been confirmed that death rate increased more than each separate administration of those drugs.
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