Serious & occasionally fatal hypersensitivity reactions. Discontinue in case of severe hypersensitivity reactions. History of non-severe hypersensitivity to other β-lactam agents; patients w/ gram -ve aerobic infections. Consider diagnosis of Clostridium difficile-
associated diarrhea in patients who present w/ diarrhea during or subsequent to administration. Prolonged use may result in the overgrowth of non-susceptible organisms (eg, enterococci, fungi). False +ve may occur w/ copper reduction methods (Benedict's, Fehling's, Clinitest). +ve direct antiglobulin test (DAGT or Coombs' test) seroconversion & potential risk of hemolytic anemia. Controlled Na diet. Concurrent treatment w/ high doses of cephalosporins & nephrotoxic drugs eg, aminoglycosides or potent diuretics (eg, furosemide). Renal impairment. May influence ability to drive & use machines. Pregnancy & lactation.