Cefpirome is given by intravenous injection over 3 to 5 minutes or infusion over 20 to 30 minutes as the sulfate, but doses are expressed in terms of the base; 1.19 g of cefpirome sulfate is equivalent to 1 g of cefpirome. The usual dose is the equivalent of 1 to 2 g of cefpirome every 12 hours. For details of reduced doses to be used in renal impairment, see as follows.
Administration in renal impairment: Dosage of cefpirome should be modified in renal impairment; after a loading dose of 1 or 2g depending on the severity of the infection, the maintenance dosage should be adjusted according to creatinine clearance (CC) and the severity of infection: CC 20 to 50 ml/minute: 0.5 or 1 g twice daily.
CC 20 to 50 ml/minute: 0.5 or 1 g twice daily.
CC 5 to 20 ml/minute: 0.5 or 1 g once daily.
CC 5 ml/minute or less (in haemodialysis patients): 0.5 or 1 g once daily a half-dose after dialysis session.