Zeferom Mechanism of Action



Singapore Pharmawealth Lifesciences


Phil Pharmawealth


Phil Pharmawealth
Full Prescribing Info
Pharmacology: Cefpirome is a fourth generation cephalosporin that is stable to a wide range of beta-lactamases. It has a spectrum of activity similar to that of the third generation cephalosporin cefotaxime, but it appears to be more active in vitro against staphylococci, some enterococci, some Enterobacteriaceae, and Pseudomonas aeruginosa. Cefpirome may be less active than ceftazidime against P. aeruginosa.
Pharmacokinetics: Cefpirome is given by injection as the sulfate. Mean peak serum concentrations of 80 to 90 micrograms/mL are attained after a single intravenous 1g dose. The elimination half-life is about 2 hours and is prolonged in patients with renal impairment. Cefpirome is less than 10% bound to plasma proteins.
Cefpirome is widely distributed into body tissues and fluids and appears in breast milk. It is mainly excreted by the kidneys and 80 to 90% of a dose is recovered unchanged in the urine. Significant amounts are removed by haemodialysis.
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