Zeferom Special Precautions



Singapore Pharmawealth Lifesciences


Phil Pharmawealth


Phil Pharmawealth
Full Prescribing Info
Special Precautions
Immunological studies have suggested that up to 20% of penicillin-sensitive patients may also be allergic to cephalosporins although clinical studies indicated a lower frequency and the true incidence is uncertain; great care should be taken if cefpirome is to be given such patients. Care is also necessary in patients with a history of allergy.
Cefpirome should be given with caution to patients with renal impairment; dosage reduction may be necessary. Renal and haematological status should be monitored especially during prolonged and high-dose therapy. Cefpirome and some other cephalosporins and cephamycins (ceforanide, cefotetan, cefoxitin) may interfere with the Jaffe method of measuring creatinine concentrations and may produce falsely high values; this should be borne in mind when measuring renal function. Positive results to the dire Coombs test have been found during treatment with cefpirome and these can interfere with blood cross-matching. The urine of patients being treated with cefpirome may give false-positive reactions for glucose using copper-reduction reactions.
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