Patients who receive an overdose should be carefully observed and given supportive treatment. In the presence of renal insufficiency, hemodialysis, not peritoneal dialysis, is recommended to aid in the removal of cefepime from the body. Accidental overdosing might occur if large doses are given to patients with reduced renal function. In clinical trials, its over dosage occurred in a patient with renal failure (creatinine clearance <11 mL/min) who received 2g q24h for 7 days. The patient exhibited seizures, encephalopathy, and neuromuscular excitability.