Concise Prescribing Info
Contents
Cefoxitin Na
Indications/Uses
Anaerobic infections outside the CNS eg, intra-abdominal abscesses due to bowel perforation, pelvic infection. Surgical chemoprophylaxis eg, colorectal, appendectomy.
Dosage/Direction for Use
Administer by deep IM inj or slow IV inj over 3-5 min or by intermittent or continuous IV infusion. Adult 1 or 2 g 8 hrly. Severe infections Up to 12 g daily. Childn & neonate 20-40 mg/kg 12 hrly for neonates up to 1 wk of age, 8 hrly for 1-4 wk & 6-8 hrly for older infant & childn. Severe infections 200 mg/kg daily up to a max of 12 g daily. Uncomplicated UTI 1 g IM bid. Adult w/ renal impairment Initial loading dose: 1-2 g. Uncomplicated gonorrhea 2 g IM as a single dose w/ oral probenecid 1g. Surgical prophylaxis Adult Usual dose: 2 g IM or IV 30-60 min prior to procedure then 6 hrly, not usually for >24 hr. Infant & childn 30-40 mg/kg at the same adult interval. Neonate 30-40 mg/kg 8-12 hrly. Caesarean section 2 g as a single dose as IV to be given as soon as the umbilical section is clamped. May adjust to 3-dose regimen, w/ further 2-g doses 4 & 8 hr after the initial dose.
Contraindications
Hypersensitivity to cefoxitin or to other cephalosporins. Porphyria.
Special Precautions
Patients w/ renal impairment. Monitor renal & hematological status especially during prolonged & high-dose therapy. May interfere w/ Jaffe method & produce false high values, +ve Coombs' test, false +ve reactions for glucose using copper-reduction reactions.
Adverse Reactions
Hypersensitivity reactions including skin rash, urticaria, eosinophilia, fever, serum sickness-like reactions, anaphylaxis.
Drug Interactions
Reduced renal clearance w/ probenecid.
MIMS Class
Cephalosporins
ATC Classification
J01DC01 - cefoxitin ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Zepotin powd for inj 1 g
Packing/Price
10 × 1's
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