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Concise Prescribing Info
Cefuroxime axetil
Susceptible infections including bone & joint infections, bronchitis, gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin infections & UTI. Prophylaxis for surgical infection.
Dosage/Direction for Use
Adult 250 mg bid. Mild to moderate lower resp infections (eg, bronchitis) 250 mg bid. Severe lower resp tract infections or if pneumonia is suspected 500 mg bid. UTI 125 mg bid. Pyelonephritis 250 mg bid. Uncomplicated gonorrhea 1 g as a single dose. Lyme disease Adult & childn >12 yr 500 mg bid for 20 days. Sequential therapy: Pneumonia 1.5 g bid IV/IM for 48-72 hr, followed by 500 mg bid oral therapy for 7 days. Acute exacerbations of chronic bronchitis 750 mg bid IV/IM for 48-72 hr, followed by 500 mg bid oral therapy for 5-7 days. Childn 125 mg bid or 10 mg/kg bid. Max: 250 mg daily. Otitis media Childn >2 yr 250 mg bid or 15 mg/kg bid: Max: 500 mg daily; <2 yr 125 mg bid or 10 mg/kg bid. Max: 250 mg daily.
Should be taken with food: Take immediately after meals for optimum absorption.
Hypersensitivity to cephalosporins.
Special Precautions
Prolonged use may result to overgrowth of non-susceptible microorganisms. Concurrent use w/ potent diuretics. History of colitis. Patients w/ GI malabsorption. Pregnancy & lactation. Childn <3 mth.
Adverse Reactions
GI disturbances including diarrhea, nausea, vomiting & abdominal pain. Renal dysfunction, toxic nephropathy, hepatic cholestasis, aplastic anemia, hemolytic anemia, hemorrhage; increased prothrombin time, BUN, creatinine, alkaline, phosphatase, neutropenia, thrombocytopenia, leukopenia; elevated bilirubin, pancytopenia, & agranulocytosis; false +ve test for urinary glucose. Seizures.
Drug Interactions
Increased area under the mean serum conc time curve w/ probenecid. +ve Coombs' test w/ cephalosporins.
MIMS Class
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Zinaf tab 250 mg
Zinaf tab 500 mg
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