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Other fibrates: increased risk of adverse events such as rhabdomyolysis.
Oral anticoagulants: increase the effect of the oral anticoagulant with the risk of hemorrhage (due to their displacement from plasma proteins).
More frequent checks on the prothrombin index are necessary expressed as International Normalised Ratio (INR) and the adjustment of the dose of oral anticoagulant during the treatment with fenofibrate and for 8 days after stopping it.
Ciclosporin: With decrease in creatinine clearance and rises in serum creatinine can cause nephrotoxicity.
The primary route of elimination of fibrate drugs is thru renal excretion.
