Rarely shock may occur. Therefore careful observation is required. In the event of symptoms such as dropping of blood pressure, dyspnea and thoracic compression, administration is discontinued and appropriate measures are taken.
In the event of hypersensitivity such as eruption, flare, pruritus, edema, fever, serum sickness-like syndrome, photosensitivity reaction with vesicle or erythema, therapy should be discontinued.
Rarely petechia, erythema multiforme, erythema nodosum, fixed drug eruption, life threatening mucocutaneous ocular syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome) or fixed eruption may occur. Therefore careful observation is required. In the event of symptoms administration is discontinued.
Occasionally elevation of BUN and serum creatinine, rarely acute renal failure, renal dysfunction, vaginal candidiasis, hematuria, crystalluria, interstitial nephritis may occur.
Occasionally abnormal hepatic function value (increase of ALT, AST and ALP, bilirubinemia) rarely jaundice, cholestatic jaundice, hepatitis, hepatic necrosis (very rarely progressed to hepatic failure life threatening hepatic failure) may occur. Therefore careful observation is required. In the event of symptoms administration is discontinued and appropriate measures are taken.
Agranulocytosis, pancytopenia (very rarely life threatening) may occur. Occasionally leukopenia, thrombocytopenia, eosinophilia, rarely leukocytosis, erythrocytopenia, decrease of hemoglobin, decrease of hematocrit value, anemia, granulocytopenia, leukocytolysis, change of prothrombin value, thrombocytopenia, thrombocythemia, hemolytic anemia, petechia or myelosuppression (life threatening) may occur. Therefore careful observation is required. In the event of symptoms administration is discontinued.
Colitis accompanying hemafecia including pseudomembranous colitis (rarely life threatening) may occur. In the event of abdominal pain and frequent diarrhea, administration is discontinued and appropriate measures are taken. Occasionally anorexia, diarrhea, abdominal discomfort, nausea, vomiting, abdominal pain, abdominal distension and rarely stomatitis, oral candidiasis, GI candidiasis or pancreatitis may occur.
Occasionally headache, dizziness, insomnia, agitation, alienation rarely sensory paralysis of tongue, drowsiness, tremolo, visual disturbance, hallucination, sweating, paresthesia (peripheral paraplegia), anxiety, nightmares, depression, tremor, convulsion, hypoesthesia, convulsive seizure, gait disturbance, psychosis, intracranial hypertension, ataxia, hyperesthesia, hypertonia or single twitch may occur. Attack or sleep disorder may occur.
Muscle pain, muscular weakness, elevated CPK, rhabdomyolysis accompanying aggravation of renal function with elevation of myoglobin in urine or blood may occur. Therefore careful administration is required. Occasionally joint pain, rarely arthredema, myasthenia, tenontitis (Achilles tenontitis), tendon rupture (Achilles tendon rupture) may occur. Severe myasthenia may be aggravated.
Interstitial pneumonia accompanying with fever, cough, dyspnea disorder of chest X-ray, eosinophilia may occur. In occurrences of these symptoms, appropriate treatment including adrenocorticosteroid are taken.
Body as a whole:
Occasionally candidiasis, anergia (weakness fatigue), rarely pain, melalgia, back pain, chest pain or joint pain may occur.
Occasionally dysgeusia, rarely tinnitus, transient hearing loss, visual disturbance, double vision, chromatopsia, dysgeusia, olfactory disorders, anosmia (reversibly after drug discontinuation).
Rarely edema (peripheral, vessel, facial, Pharyngeal), hyperglycemia, increase of amylase. Increase of lipase may occur. Hypoglycemia has rarely reported in other new quinolone antibiotics (elderly person, particularly with renal failure).
Occasionally (thrombotic) phlebitis, rarely frequent pulse, migraine, syncope, angiectasia (flushing), hypotension, vasculitis, petechia, bleeding blister, acne, crust formation may occur.
Local I.V. site reactions have been reported with the intravenous administration of ciprofloxacin. These reactions are more frequent if the infusion time is 30 minutes or less. These may appear as local skin reactions which resolve rapidly upon completion of the infusion. Subsequent intravenous administration is not contraindicated unless the reactions recur or worsen.