Zoldem Overdosage





United Lab
Full Prescribing Info
Overdosage with zolpidem tartrate alone or in combination with CNS depressant agents resulted in impairment of consciousness ranging from somnolence to coma, cardiovascular and/or respiratory compromise, and fatal outcomes.
General symptomatic and supportive measures should be used along with immediate gastric lavage as necessary. Intravenous fluids should be given as needed. Flumazenil is shown to reduce zolpidem tartrate sedative hypnotic effect and therefore, may be useful; however, flumazenil's use may contribute to the appearance of neurological symptoms such as convulsions. Respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures should be employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. Even if excitation occurs, sedating drugs should be withheld after zolpidem tartrate overdosage. The importance of dialysis in the treatment of overdosage has not been determined, although hemodialysis studies in patients with renal failure receiving therapeutic doses have shown zolpidem tartrate to be not dialyzable.
The possibility of multiple drug ingestion should be considered in the management of zolpidem tartrate overdosage.
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