Patients must be supplemented w/ Ca & vit D. Adequately rehydrate patients w/ malignant hypercalcemia prior to administration for inj & monitor electrolytes during treatment. Osteonecrosis of the jaw; severe & occasionally incapacitating bone, joint &/or muscle pain. Patients w/ asthma. Avoid invasive dental procedures. Bronchoconstriction in aspirin-sensitive patients. Do not mix w/ Ca-containing infusion soln. Concomitant use w/ nephrotoxic drugs. Monitor serum creatinine before each dose. Not recommended to renal (severe) & hepatic impairment. Not to be used during pregnancy. Not indicated for childn.