Zolid: Zolid tablets are taken once daily with or without meals and should be taken about the same time everyday. However, skipping meals while taking this medicine is not advised. Zolid can cause hypoglycemia.
Adults: Monotherapy: Initial Dose: 15 or 30 mg once daily, increasing after 4 weeks to 45 mg once daily if greater therapeutic effect is needed.
Combination Therapy: Zolid in Combination with Sulfonylureas, Insulin or Metformin: Initial dose: 15 or 30 mg once daily. It may be possible to achieve metabolic control at a reduced dose of sulfonylurea, insulin or metformin. If there is a particular risk of hypoglycemia, pioglitazone can be introduced at a dose of 15 mg. For patients already on insulin, pioglitazone should be introduced at a dose of 15 mg once daily.
Maximum Recommended Dose: 45 mg once daily since doses >45 mg once daily have not been studied.
Hepatic Impaired Patients: The intrinsic clearance of pioglitazone may be reduced in patients with hepatic disease. Dosage should start at 15 mg and be increased cautiously.
ZolidPlus: The use of antihyperglycemic therapy in the management of type 2 diabetes should be individualized on the basis of effectiveness and tolerability while not exceeding the maximum recommended daily dose of pioglitazone 45 mg and metformin 2550 mg. Selecting the starting dose of ZolidPlus should be based on the patient's current regimen of pioglitazone and/or metformin.
Starting Dose for Patients Inadequately Controlled on Metformin Monotherapy: Based on the usual starting dose of pioglitazone 15-30 mg daily, ZolidPlus may be initiated at 15 mg/500 mg tablet once or twice daily and gradually titrated after assessing adequacy of therapeutic response.
Starting Dose for Patients Who Initially Responded to Pioglitazone Monotherapy and Require Additional Glycemic Control: Based on the usual starting doses of metformin 500 mg twice daily or 850 mg daily, ZolidPlus may be initiated at 15 mg/500 mg twice daily and gradually titrated after assessing adequacy of therapeutic response.
Starting Dose for Patients Switching from Combination Therapy of Pioglitazone + Metformin as Separate Tablets: ZolidPlus may be initiated with 15 mg/500 mg tablet based on the dose of pioglitazone and metformin already being taken.
Administration: ZolidPlus should be given in daily divided doses with meals to reduce the gastrointestinal side effects associated with metformin.