Zonia-5

Zonia-5

olanzapine

Manufacturer:

Sydler Remedies

Distributor:

Ambica
Concise Prescribing Info
Contents
Olanzapine
Indications/Uses
Schizophrenia. Effective in maintaining the clinical improvement during continuing therapy in patients who have shown initial treatment response. Short-term treatment of acute manic episode associated w/ bipolar I disorder. Prevent recurrence of manic, mixed or depressive episodes in bipolar I disorder.
Dosage/Direction for Use
Adult Monotherapy Initially 10 or 15 mg once daily. Adjust dose at intervals of not <24 hr & increments/decrements of 5 mg once daily if necessary. Maintenance: 5-20 mg once daily for 2 wk. Short-term (3-4 wk) antimanic efficacy 5-20 mg/day. Max: 20 mg/day. Adjunctive treatment to lithium or valproate Initially 10 mg once daily. Adolescent Bipolar I disorder Initially 2.5 or 5 mg once daily w/ target dose of 10 mg/day. Dose range: 2.5-20 mg/day w/ mean modal dose of 10.7 mg/day (mean dose of 8.9 mg/day). Adjust dose at increments/decrements of 2.5 or 5 mg if necessary.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Increased risk of death & incidence of cerebrovascular events (eg, stroke, transient ischaemic attack) in elderly patients. Monitor for suicidal ideations. Discontinue if neuroleptic malignant syndrome & tardive dyskinesia develops. Monitor for symptoms of hyperglycemia; hyperlipidemia (include fasting blood lipid/glucose testing & lipid profiles at the beginning of & periodically during therapy); wt regularly. Patients w/ CV & cerebrovascular disease, conditions affecting hemodynamic responses; history of low WBC or drug-induced leukopenia/neutropenia; history of seizures or conditions that potentially lower seizure threshold. May elevate prolactin levels. Concomitant use w/ fluoxetine, lithium or valproate. May impair ability to drive & operate machinery.
Adverse Reactions
Agitation or hostile, angry behavior, changes in emotions or behavior (depressed mood), restlessness or need to keep moving, stiffness, spasms, tremors or trembling; constipation, dizziness (especially on standing from sitting or lying position), drowsiness, dry mouth, lowered BP, runny nose, wt gain.
Drug Interactions
May potentiate orthostatic hypotension w/ diazepam & alcohol. Increased clearance w/ carbamazepine & levels w/ fluvoxamine. CNS-acting drugs. Enhanced effect of antihypertensives. May antagonize levodopa/dopamine agonists. Lithium or valproate.
MIMS Class
ATC Classification
N05AH03 - olanzapine ; Belongs to the class of diazepines, oxazepines and thiazepines antipsychotics
Presentation/Packing
Form
Zonia-5 FC tab 5 mg
Packing/Price
30's
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