Autonomic Nervous System:
Blurred vision, dry mouth, constipation, ileus, nasal stuffiness, photophobia.
Hypotension can occur after oral administration. Tolerance to hypotensive effects generally develop over time, it can persist in some patients, especially the elderly.
Zycloran has peripheral alpha-adrenergic blocking activity. Its effects on the ECG include prolongation of the PR and QT intervals blunting of the T-wave and depression of the S-T segment. Ventricular arrhythmia and sudden death have occurred rarely.
Extrapyramidal reactions, including pseudoparkinsonism (with motor retardation, rigidity, drooling, tremors etc.), dystonic reactions (including perioral spasms, tics, torticollis, protrusion of the tongue etc.) and akathisia. Dizziness has been reported.
Tardive dyskinesia may appear in some patients on long term antipsychotic therapy.
Elderly patients are affected greatly, especially females. The symptoms are persistent and in some patients appear to be irreversible.
Itching, skin rash, erythema, allergic purpura, exfoliative dermatitis, photosensitivity.
Increased prolactin secretion, gynecomastia, galactorrhea, mastalgia, altered libido, menstrual irregularities, weight gain, alterations in glucose tolerance and false positive pregnancy tests have occurred.
Nausea, vomiting, increase or decrease in appetite, gastric irritation, constipation, paralytic ileus, rarely diarrhea.
Urinary retention, priapism, inhibition of ejaculation.
Agranulocytosis, leukopenia, granulocytopenia, eosinophilia, thrombocytopenia, anemia, aplastic anemia, pancytopenia. Agranulocytosis occurs in fewer than 1 in 10,000 patients.
Jaundice usually occurs within 2 to 4 weeks of initiation of therapy and should be discontinued immediately. Rarely progression to chronic jaundice has occurred. Pre-existing liver dysfunction has not yet been proven to be a risk factor for this reaction. Signs and symptoms of cholestatic jaundice include upper abdominal pain, nausea, flu-like symptoms, yellow skin and conjunctiva, fever, elevated liver enzymes, biliuria.
Pigmentation of areas of conjunctiva and/or discoloration of the exposed sclera and cornea. Patients receiving higher dose for prolonged periods should have periodic complete eye examinations.