Zyloprim

Zyloprim

allopurinol

Manufacturer:

Aspen

Distributor:

Zuellig
Concise Prescribing Info
Contents
Allopurinol
Indications/Uses
Clinical manifestations of urate/uric acid deposition eg, idiopathic gout, uric acid lithiasis; gouty arthritis, skin tophi &/or renal involvement, hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose-6-phosphatase including glycogen storage disease; phosphoribosylpyrophosphate synthetase; phosphoribosylpyrophosphate aminotransferase; adenine phosphoribosyltransferase. Management of 2,8-dihydroxyadenine renal stones related to deficient activity of adenine phosphoribosyltransferase. Management of recurrent mixed Ca oxalate renal stones in the presence of hyperuricosuria, when fluid, dietary & similar measures have failed.
Dosage/Direction for Use
Adult 2-10 mg/kg body wt/day. Mild conditions 100-200 mg daily. Moderately severe conditions 300-600 mg daily. Severe conditions 700-900 mg daily. Childn <15 yr 10-20 mg/kg body wt/day. Max: 400 mg/day.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Asymptomatic hyperuricemia.
Special Precautions
Hepatic or renal impairment (reduce dose). Initiate therapy after acute gout attack has subsided. Malignant diseases & its treatment, Lesch-Nyhan syndrome. Possibility of impaction of uric acid renal stones. May impair ability to drive or operate machinery. Pregnancy & lactation.
Drug Interactions
6-mercaptopurine & azathioprine; vidarabine; uricosurics eg, probenecid & large doses of salicylates; chlorpropamide; warfarin & other coumarin anticoagulants; phenytoin; theophylline; ampicillin/amoxicillin; cyclophosphamide, doxorubicin, bleomycin, procarbazine, mechlorocthamine; cyclosporine; didanosine.
MIMS Class
Hyperuricemia & Gout Preparations
ATC Classification
M04AA01 - allopurinol ; Belongs to the class of preparations inhibiting uric acid production. Used in the treatment of gout.
Presentation/Packing
Form
Zyloprim tab 100 mg
Packing/Price
100's (P839.14/pack)
Form
Zyloprim tab 300 mg
Packing/Price
100's (P2,383.78/pack)
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in