Zypezil 5/Zypezil 10

Zypezil 5/Zypezil 10



Cadila Healthcare


Zydus Healthcare Phils
Concise Prescribing Info
Donepezil HCl
Symptomatic treatment of mild to moderately severe Alzheimer's dementia.
Dosage/Direction for Use
Adult/elderly Initially 5 mg/day & should be maintained for 1 mth. May be increased to 10 mg/day after 1 mth of clinical assessment of treatment. Max: 10 mg daily.
May be taken with or without food: Take at bedtime.
Hypersensitivity to donepezil HCl or piperidine derivatives.
Special Precautions
Patients w/ severe Alzheimer's dementia, other types of dementia or other types of memory impairment (eg, age-related cognitive decline). Exaggerate succinylcholine-type muscle relaxation during anaesth. Sick sinus syndrome or other supraventricular cardiac conduction conditions eg, SA or AV block. Patients at increased risk of developing ulcers eg, those w/ history of ulcer disease or those receiving concurrent NSAIDs should be monitored for symptoms. May cause bladder outflow obstruction. Exacerbate or induce extrapyramidal symptoms. Patients w/ history of asthma or obstructive pulmonary disease. Avoid concomitant use w/ other inhibitors of acetylcholinesterase, agonists or antagonists of the cholinergic system. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Minor or moderate influence on the ability to drive & use machines. Severe hepatic impairment. Pregnancy & lactation. Not recommended for childn.
Adverse Reactions
Diarrhoea, muscle cramps, fatigue, nausea, vomiting & insomnia.
Drug Interactions
Inhibited metabolism w/ ketoconazole, quinidine, itraconazole, erythromycin & fluoxetine. Increased mean conc w/ ketoconazole. May reduce levels w/ rifampicin, phenytoin, carbamazepine & alcohol. Potential to interfere w/ medications having anticholinergic activity. Potential for synergistic activity w/ succinylcholine, other neuromuscular blocking agents or cholinergic agents or β-blocking agents.
ATC Classification
N06DA02 - donepezil ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Zypezil 10 FC tab 10 mg
Zypezil 5 FC tab 5 mg
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