Zyphrine Dosage/Direction for Use



Stallion Labs


Cathay Drug
Full Prescribing Info
Dosage/Direction for Use
Adults and Children 12 years of Age and Older: The recommended dose is 2 teaspoon (10 mL) oral once daily in the evening. Some patients may be adequately controlled by 1 teaspoon (5 mL) oral solution once daily in the evening.
Children 6 to 11 Years of Age: The recommended dose is 1 teaspoon (5 mL) once daily in the evening. The 2.5 mg should not be exceeded because the systemic exposure with 5 mg is approximately twice that of adults.
Children 6 months to 5 Years of Age: The recommended dose is 1.25 mg (½ teaspoon oral solution) [2.5 mL] once daily in the evening. The 1.25 mg once daily should not be exceeded based on comparable exposure to adults receiving 5 mg.
Elderly with Renal Impairment: Adjustment of the dose is recommended in elderly patients with moderate to severe renal impairment (see Renal Impairment as follows)
Renal Impairment: The dosing intervals must be individualized according to renal function. Refer to the table as follows and adjust the dose as indicated. To use dosing table an estimate of the patients CrCl in mL/min is needed. (See table.) The CrCl (mL/min) may be estimated from serum creatinine (mg/dL) determined using the following formula: See equation.

Click on icon to see table/diagram/image

Dosing adjustment for Patients with Impaired Renal Function: See table.

Click on icon to see table/diagram/image

In pediatric patients suffering from renal impairment, the dose will have to be adjusted on an individual basis, taking into account the renal clearance of the patient and their body weight. There are no specific data for children with renal impairment.
Hepatic Impairment: No dose adjustment is needed in patients with solely hepatic impairment. In patients with hepatic and renal impairment, adjustment of the dose is recommended (see Renal Impairment as previously mentioned).
Duration of Use: Intermittent allergic rhinitis (symptoms <4 days/week or during <4 weeks) has to be treated according to the disease and its history; it can be stopped once the symptoms have disappeared and can be restarted again when symptoms reappear. In case of persistent allergic rhinitis (symptoms >4 days/week and during >4 weeks), continuous therapy can be proposed to the patient during the period of exposure to allergens.
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