Zyrova

Zyrova

rosuvastatin

Manufacturer:

Cadila Healthcare

Distributor:

Metro Drug

Marketer:

Zydus Healthcare Phils
Concise Prescribing Info
Contents
Rosuvastatin Ca
Indications/Uses
Primary hypercholesterolemia (type II a), mixed dyslipidemia (type II b), or homozygous familial hypercholesterolemia in patients who have not responded adequately to diet & other appropriate measures.
Dosage/Direction for Use
Usual recommended starting dose: 10 mg once daily. Patient requiring less aggressive LDL-C reductions/predisposed to myopathy Initially 5 mg once daily. Marked hypercholesterolemia (LDL-C >190 mg/dL) Initially 20 mg. Patient who have not achieved goal LDL-C at 20 mg 40 mg. Severe renal impairment (CrCl <30 mL/min/m2) Initially 5 mg once daily. Max dose: 10 mg.
Administration
May be taken with or without food.
Contraindications
Patients w/ active liver disease including unexplained persistent elevations of serum transaminases. Pregnancy & lactation.
Special Precautions
Perform liver function tests prior to & 12 wk following both the initiation & any elevation of dose & periodically thereafter. Patients who consume alcohol, history of liver disease; diffuse myalgias, muscle tenderness/weakness. Discontinue therapy if CPK levels >5x the upper limit of normal occur. Acute, serious condition suggestive of myopathy or risk factor to renal failure secondary to rhabdomyolysis (eg, severe acute infection, hypotension, major surgery, trauma, severe metabolic endocrine & electrolyte disorders, uncontrolled seizures); risk factors to myopathy eg, renal impairment, elderly & hypothyroidism.
Adverse Reactions
Myalgia, constipation, asthenia, abdominal pain & nausea.
Drug Interactions
Cyclosporine, fibrates, niacin, gemfibrozil, itraconazole, warfarin, antacids containing albumin & MgOH2, erythromycin, OC.
ATC Classification
C10AA07 - rosuvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.
Presentation/Packing
Form
Zyrova FC tab 10 mg
Packing/Price
100's (P21.43/film-coated tab)
Form
Zyrova FC tab 20 mg
Packing/Price
100's (P31.25/film-coated tab)
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