Acalabrutinib - oral

Patient Medicine Information
Why do I need this medicine?
Acalabrutinib is used on its own or together with other medicines to treat certain types of cancers of the lymphocytes (a type of white blood cells in the body that help fight infection) including Mantle cell lymphoma, chronic lymphocytic leukaemia and small lymphocytic lymphoma.
How do I take this medicine?
Take Acalabrutinib exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your condition.

Acalabrutinib must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
If you miss a dose and it is more than 3 hours after your usual dosing time, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have severe liver disease as Acalabrutinib may not be suitable for you.

Do not take this medicine if you are pregnant. If you become pregnant while on Acalabrutinib therapy, alert your doctor immediately. This medicine may cause harm to your unborn child.

It is important that you do not get pregnant while being treated with Acalabrutinib. You may wish to discuss birth control methods with your doctor or pharmacist. Avoid pregnancy for at least 1 week after you stop taking this medicine.

Do not breastfeed while you are being treated with this medicine and for at least 2 weeks after your last dose.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • heart disease e.g. irregular heartbeat 
  • high blood pressure
  • current or at risk of infection
If you are going to have an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Pregnancy tests must be done before treatment to know if this medicine is suited for you to take.
  • Routine blood tests may be done while you are being treated with this medicine.
  • Regular monitoring of signs and symptoms of infection, irregular heartbeat, and bleeding may also be needed.
Your doctor will advise you about how often you need to have these tests.
What side effects could I experience?
Acalabrutinib may cause tiredness and dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: nausea, vomiting, diarrhoea, stomach pain, constipation, muscle pain and rash.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • pass out bloody stools or black as tar and vomiting blood, or ground coffee-like material
  • severe headache, weakness in the arm or leg, tingling or numbness, seizures
  • coughing, shortness of breath, extreme fatigue
  • chest pain, irregular heartbeat, weakness, lightheadedness
  • fever, chills, severe sore throat
This medicine will cause the level of your red blood cells, white blood cells and platelets to drop.

Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.

White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, or a cough or flu that does not go away.

Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • gastric medicines e.g. omeprazole
  • medicines for epilepsy (fits or seizure) e.g. carbamazepine, phenytoin
  • medicine to treat TB (a lung infection known as tuberculosis) e.g. rifampicin
  • certain antibiotics e.g. erythromycin, clarithromycin
  • medicines to treat fungal infection e.g. fluconazole, itraconazole
  • medicines for HIV infection e.g. indinavir
  • diltiazem (medicine for high blood pressure or heart disease)
  • blood-thinning medicines e.g. warfarin, heparin
This list does not include all medicines that may interact with Acalabrutinib.

Acalabrutinib should not be taken with antacids (e.g. calcium carbonate) or acid reducers (e.g. ranitidine, famotidine) as these could reduce the effectiveness of this medicine. If you must take antacids, take it either 2 hours before or after you have taken this medicine. If you must take acid reducers, take it 2 hours after you have taken this medicine.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on acalabrutinib - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by
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