Significant: Idiosyncratic infusion-related reactions (e.g. headache, nausea, rigors, pyrexia, flushing, fatigue), hypersensitivity reactions (including anaphylactic reactions), IgG antibody development.
Cardiac disorders: Palpitations, atrial fibrillation, tachycardia, chest pain or tightness.
Ear and labyrinth disorders: New-onset or aggravated tinnitus.
Eye disorders: Lacrimation increased, corneal reflex decreased.
Gastrointestinal disorders: Vomiting, abdominal pain or discomfort, diarrhoea, dysgeusia.
General disorders and administration site conditions: Peripheral oedema, asthenia, pain or discomfort, aggravated fatigue, feeling hot or cold, influenza-like illness, malaise, inj site rash.
Musculoskeletal and connective tissue disorders: Arthralgia, myalgia, back pain, pain in limb, joint swelling, musculoskeletal discomfort, peripheral swelling.
Nervous system disorders: Dizziness, neuropathic pain, tremor, paraesthesia, hypoaesthesia.
Psychiatric disorders: Hypersomnia.
Respiratory, thoracic and mediastinal disorders: Cough, dyspnoea, nasopharyngitis, pharyngitis, throat tightness, rhinorrhoea, hoarseness.
Skin and subcutaneous tissue disorders: Rash, acne, urticaria, erythema, pruritus, hyperhidrosis, livedo reticularis.
Vascular disorders: Hypertension, hypotension.