Amaryl

Amaryl

glimepiride

Manufacturer:

sanofi-aventis

Distributor:

DKSH
Concise Prescribing Info
Contents
Glimepiride
Indications/Uses
Alone or in combination w/ insulin or metformin in the treatment of NIDDM.
Dosage/Direction for Use
Initially 1 mg once daily. Usual maintenance dose: 1-4 mg once daily. Max daily dose: 6 mg. Amaryl may also be used in combination w/ insulin or metformin.
Administration
Should be taken with food: Take immediately before the 1st main meal of the day. Do not skip meals. Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity to glimepiride, sulfonylureas or sulfonamides. Insulin-dependent (type 1) DM; diabetic ketoacidosis; diabetic coma; severe renal or hepatic dysfunction.
Special Precautions
Regular monitoring of glucose levels in blood & urine, hepatic & haematological function. Temporary changeover to insulin in stress situations (eg, accidents, acute operations, infections w/ fever). G6PD deficiency & other cellular metabolic disorders known to cause haemolytic anaemia. Dialysis patients. Patients w/ rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Pregnancy & lactation. Childn.
Adverse Reactions
Rarely, hypoglycaemia; dysgeusia, alopecia, wt gain; thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, erythropenia, haemolytic anaemia & pancytopenia.
Drug Interactions
May influence metabolism in concomitant w/ CYP2C9 inducers (eg, rifampicin) or inhibitors (eg, fluconazole). Increased AUC w/ fluconazole. Potentiation of the blood glucose-lowering effect by phenylbutazone, azapropazone, oxyfenbutazone, insulin & oral antidiabetic (eg, metformin), salicylates, p-aminosalicylic acid, anabolic steroids & male sex hormones, chloramphenicol, certain long-acting sulfonamides, tetracyclines, quinolone antibiotics & clarithromycin, coumarin anticoagulants, fenfluramine, disopyramide, fibrates, ACE inhibitors, fluoxetine, MAOIs, allopurinol, probenecid, sulfinpyrazone, sympatholytics, cyclophosphamide, trophosphamide & iphosphamides, miconazole, fluconazole, pentoxifylline (high dose parenteral), tritoqualine. Weakening of the blood glucose-lowering effect by oestrogens & progestogens; saluretics, thiazide diuretics; thyroid stimulating agents, glucocorticoids; phenothiazine derivatives, chlorpromazine; adrenaline & sympathicomimetics; nicotinic acid (high doses) & nicotinic acid derivatives; laxatives (long term use); phenytoin, diazoxide; glucagon, barbiturates & rifampicin; acetazolamide. May potentiate or weaken blood glucose-lowering effect by H2-antagonists, β-blockers, clonidine, guanethidine & reserpine. Alcohol intake may potentiate or weaken the hypoglycaemic action. May potentiate or weaken the effects of coumarin derivatives. Reduced GIT absorption w/ colesevelam.
MIMS Class
ATC Classification
A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.
Presentation/Packing
Form
Amaryl tab 3 mg
Packing/Price
30's
Form
Amaryl tab 2 mg
Packing/Price
30's
Form
Amaryl tab 1 mg
Packing/Price
30's
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