Amtas

Amtas

amlodipine

Manufacturer:

Intas

Distributor:

Apotheca Marketing
Concise Prescribing Info
Contents
Amlodipine besylate
Indications/Uses
1st-line treatment of HTN; can be used as the sole agent to control BP in the majority of patients. Symptomatic treatment of chronic stable angina, used alone or in combination w/ other antianginal drugs. Confirmed or suspected vasospastic angina, as monotherapy, or in combination w/ other antianginal drugs. Reduce risk of hospitalization due to angina & risk of a coronary revascularization procedure in patients w/ recently documented CAD by angiography & w/o heart failure or an ejection fraction <40%,
Dosage/Direction for Use
HTN & angina Initially 5 mg once daily. Max: 10 mg. CAD 5-10 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to amlodipine or to other dihydropyridines. Pregnancy & lactation.
Special Precautions
Hepatic impairment. Pregnancy & lactation. Childn.
Adverse Reactions
Flushing; dizziness, headaches, somnolence; abdominal pain, nausea; palpitations; fatigue, oedema.
Drug Interactions
Increased simvastatin exposure. Bioavailability may be increased by grapefruit juice. Plasma conc may be increased by strong CYP3A4 inhibitors of (eg, ketoconazole, itraconazole, ritonavir). Increased risk of hypotension w/ clarithromycin. Plasma conc may be decreased by CYP3A4 inducers (eg, rifampicin, St. John's Wort). Risk of increased tacrolimus blood levels. May increase exposure of mechanistic target of rapamycin inhibitors.
ATC Classification
C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Amtas tab 5 mg
Packing/Price
10 × 10's
Form
Amtas tab 10 mg
Packing/Price
10 × 10's
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