Apalutamide - oral

Patient Medicine Information
Why do I need this medicine?
Apalutamide is used to treat male patients with prostate cancer that has not spread to other parts of the body or which no longer responds to medical or surgical treatment.
How do I take this medicine?
Take this medicine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take it together with food or immediately after a meal. Try to take it at the same time each day.

Swallow the tablet whole. Do not divide, chew or crush the tablet.

The dose of Apalutamide will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your condition and tolerability to this medicine.

This medicine must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Apalutamide is not for use in women. Do not take this medicine if you are pregnant or breastfeeding.

This medicine may cause harm to your unborn child. You must use proven birth control methods when having sexual contact with a pregnant woman or woman who can become pregnant while you are taking this medicine. Adequate contraceptive methods must be used during therapy and for a certain period of time after stopping the treatment. You may wish to discuss birth control methods with your doctor.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • history of fits or seizures or of high risk for seizures (e.g. brain injury, or recent stroke, or if you are taking medicines that may cause seizures)
  • risk of falls or fractures
  • heart disease
  • severe liver disease
  • severe kidney disease
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Routine tests (e.g. thyroid function) may be done while you are being treated with this medicine.
  • Regular monitoring of signs of seizures, skin reactions, and risk of fall and fracture may also be needed.
Your doctor will advise you about how often you need to have these tests.
What side effects could I experience?
Apalutamide may cause any of the following side effects: tiredness, weight loss, joint pain, skin rash and itching.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience seizures, falls and broken bones.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • cholesterol-lowering medicine e.g. gemfibrozil, rosuvastatin
  • medicine to treat fungal infection e.g. ketoconazole, itraconazole
  • medicines for heart rhythm problems e.g. digoxin, quinidine, disopyramide, amiodarone, sotalol
  • blood-thinning medicine e.g. dabigatran etexilate, clopidogrel
  • antibiotic e.g. moxifloxacin, clarithromycin
  • fexofenadine (medicine for cold or allergy)
  • colchicine (medicine for gout (abnormal metabolism of uric acid)) 
  • lapatinib (medicine for cancer) 
  • methotrexate (medicine for cancer)
  • repaglinide (medicine for diabetes)
  • methadone (strong painkiller)
  • haloperidol (medicine for mood disorders)
This list does not include all medicines that may interact with Apalutamide.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children. Protect from light and moisture.

As this is a cancer medicine, always return any unused or expired tablets to the clinic, hospital, or pharmacy for disposal. Do not throw it away in the household waste.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on apalutamide - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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