insulin glulisine




Concise Prescribing Info
Insulin glulisine
Adults, adolescents & childn ≥6 yr w/ DM, where treatment w/ insulin is required.
Dosage/Direction for Use
SC Individualized dosing by SC inj or continuous SC pump infusion.
Should be taken with food: Administer shortly (0-15 min) before or soon after meals.
Special Precautions
Transfer to another type or brand of insulin should be done under strict medical supervision & may require change in dose. Inadequate dosing or discontinuation of treatment. Perform continuous inj rotation to reduce the risk of developing lipodystrophy & cutaneous amyloidosis. Monitor blood glucose after change in inj site & dose adjustment. Adjust dose if to undertake increased physical activity or change in usual meal plan. Contains metacresol. Possible cardiac failure w/ insulin in patients w/ risk factors for development of cardiac heart failure. Renal & hepatic impairment. May affect ability to drive & operate machinery. Pregnancy & lactation. Childn <6 yr.
Adverse Reactions
Hypoglycaemia; inj site reactions, local hypersensitivity reactions.
Drug Interactions
May enhance blood glucose-lowering activity & increase susceptibility of hypoglycaemia by other oral antidiabetics, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates, sulfonamide antibiotics. May reduce blood glucose-lowering activity by corticosteroids, danazol, diazoxide, diuretics, glucagon, INH, phenothiazine derivatives, somatropin, sympathomimetics (eg, epinephrine, salbutamol, terbutaline), thyroid hormones, estrogens, progestins (eg, OCs), PIs & atypical antipsychotics (eg, olanzapine, clozapine). May potentiate or weaken blood glucose-lowering activity w/ β-blockers, clonidine, lithium salts or alcohol. Hypoglycaemia may sometimes followed by hyperglycaemia w/ pentamidine. Reduced or absent signs of adrenergic counterregulation w/ sympatholytics eg, β-blockers, clonidine, guanethidine & reserpine.
MIMS Class
Insulin Preparations
ATC Classification
A10AB06 - insulin glulisine ; Belongs to the class of fast-acting insulins and analogues. Used in the treatment of diabetes.
Apidra soln for inj 100 u/mL
(SoloStar) 3 mL x 1's
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