Apo-Acyclovir

Apo-Acyclovir

aciclovir

Manufacturer:

Apotex

Distributor:

Pharmaforte
Concise Prescribing Info
Contents
Acyclovir
Indications/Uses
Initial episodes of herpes genitalis; suppression of unusually frequent recurrences of herpes genitalis (≥6 episodes/yr); acute treatment of herpes zoster (shingles).
Dosage/Direction for Use
Herpes genitalis Initially 200 mg every 4 hr 5 times daily (1 g daily for 10 days). Suppressive therapy for recurrent disease Initially 200 mg tds, can be increased up to 200 mg 5 times daily, if necessary, 400 mg bd may be considered. Intermittent therapy 200 mg every 4 hr 5 times daily for 5 days. Herpes zoster 800 mg every 4 hr 5 times daily for 7-10 days. Treatment should be initiated w/in 72 hr on the onset of lesions. Acute or chronic renal impairment Normal dose: 200 mg every 4 hr 5 times daily. Adjusted dose: CrCl >10 mL/min 200 mg every 4 hr 5 times daily, 0-10 mL/min 200 mg every 12 hr. Normal dose: 400 mg every 4 hr 5 times daily. Adjusted dose: CrCl >10 mL/min 400 mg every 12 hr; 0-10 mL/min 200 mg every 12 hr. Normal dose: 800 mg every 4 hr 5 times daily. Adjusted dose: CrCl >25 mL/min 800 mg every 4 hr 5 times daily, 10-25 mL/min 800 mg every 8 hr, 0-10 mL/min 800 mg every 12 hr.
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Special Precautions
May increase risk of renal dysfunction in patients receiving potentially nephrotoxic agents. Pregnancy & lactation. Childn <2 yr.
Adverse Reactions
Nausea, vomiting, headache; diarrhea; rash, paresthesia, asthenia; malaise; constipation.
Drug Interactions
Increased mean t½ & AUC & reduced urinary excretion & renal clearance w/ probenecid.
MIMS Class
ATC Classification
J05AB01 - aciclovir ; Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Presentation/Packing
Form
Apo-Acyclovir tab 800 mg
Packing/Price
100's
Form
Apo-Acyclovir tab 200 mg
Packing/Price
100's
Form
Apo-Acyclovir tab 400 mg
Packing/Price
100's
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