Herpes genitalis Initially 200 mg every 4 hr 5 times daily (1 g daily for 10 days).
Suppressive therapy for recurrent disease Initially 200 mg tds, can be increased up to 200 mg 5 times daily, if necessary, 400 mg bd may be considered.
Intermittent therapy 200 mg every 4 hr 5 times daily for 5 days.
Herpes zoster 800 mg every 4 hr 5 times daily for 7-10 days. Treatment should be initiated w/in 72 hr on the onset of lesions.
Acute or chronic renal impairment Normal dose: 200 mg every 4 hr 5 times daily. Adjusted dose:
CrCl >10 mL/min 200 mg every 4 hr 5 times daily,
0-10 mL/min 200 mg every 12 hr. Normal dose: 400 mg every 4 hr 5 times daily. Adjusted dose:
CrCl >10 mL/min 400 mg every 12 hr;
0-10 mL/min 200 mg every 12 hr. Normal dose: 800 mg every 4 hr 5 times daily. Adjusted dose:
CrCl >25 mL/min 800 mg every 4 hr 5 times daily,
10-25 mL/min 800 mg every 8 hr,
0-10 mL/min 800 mg every 12 hr.
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