For both hypertension and angina the usual initial dose is 5 mg amlodipine once daily which may be increased to a maximum dose of 10 mg depending on the individual patient's response.
For patients with coronary artery disease the recommended dosage range is 5-10 mg once daily. In clinical studies the majority of patients required 10 mg once daily (see Pharmacology: Pharmacodynamics under Actions).
No dose adjustment of amlodipine is required upon concomitant administration of thiazide diuretics, beta-blockers and angiotensin-coverting enzyme inhibitors.
Use in the Elderly: Normal dosage regimens are recommended. Amlodipine, used at similar doses in elderly or younger patients, is equally well tolerated.
Use in Children: Safety and effectiveness of amlodipine in children have not been established.
Use in Patients with Impaired Hepatic Function: See PREACUTIONS.
Use in Renal Failure: Amlodipine may be used in such patients at normal doses. Changes in amlodipine plasma concentrations are not correlated with degree of renal impairment. Amlodipine is not dialyzable.