Apo-Amoxi

Apo-Amoxi

amoxicillin

Manufacturer:

Apotex

Distributor:

Pharmaforte
Concise Prescribing Info
Contents
Amoxycillin trihydrate
Indications/Uses
Upper resp infections (otitis media, pharyngitis, sinusitis & tonsilitis; lower resp infections (bronchitis, bronchopneumonia & lobar pneumonia; UTI (cystitis, cysto-pyelitis, urethritis, gonococcal urethritis). Prophylaxis against α-hemolytic (viridans group) streptococci before dental, oral or upper resp tract surgery or instrumentation. Prophylaxis of bacterial endocarditis. Cutaneous infections.
Dosage/Direction for Use
Infections of the upper resp or genitourinary tracts, skin & soft tissues due to susceptible strains Adult 250 mg every 8 hr. Childn <20 kg 20 mg/kg/day in divided doses every 8 hr. Severe infections or infections associated w/ organisms where sensitivity determinations require higher blood conc Adult 500 mg every 8 hr. Childn <20 kg 40 mg/kg/day in divided doses every 8 hr. Infections of the lower resp tract due to susceptible strains of the causative organism & acute otitis media Adult 500 mg every 8 hr. Childn <20 kg 40 mg/kg/day in divided doses every 8 hr. Urethritis due to non-penicillinase producing N. gonorrheae Adult & childn >45 kg 3 g as single oral dose; 1 g of oral probenecid should be administered concomitantly as well as appropriate therapy for presumptive or proven infection w/ C. trachomatis. Childn <45 kg 50 mg/kg as single dose (max: 3 g). Prevention of endocarditis 3 g 1 hr before procedure, then 1.5 g 6 hr after initial dose. Childn 50 mg/kg 1 hr before the procedure, then 25 mg/kg 6 hr after the initial dose.
Administration
May be taken with or without food.
Contraindications
History of sensitivity to penicillins or cephalosporins.
Special Precautions
Not effective against β-lactamases-producing staphylococci; serious & occasionally fatal hypersensitivity (anaphylactoid) reactions; careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins or other allergens before initiating therapy. Renal or hepatic insufficiency. Periodic assessment of renal, hepatic & hematopoeitic functions should be made during prolonged therapy. Possibility of superinfections w/ mycotic organisms or bacterial pathogens should be kept in mind during therapy; infectious mononucleosis. Pregnancy. Childn <2 yr.
Adverse Reactions
Hypersensitivity reactions (urticaria, erythematous maculopapular rashes, angioneurotic edema); nausea, loose stools & vomiting; anemia, thrombocytopenia, thrombocytopenia purpura, eosinophilia, leukopenia & agranulocytosis.
Drug Interactions
Decrease renal secretion w/ probenecid or other inhibitors of the renal acid secretory system; may increase possibility of skin rash. Tetracycline, chloramphenicol & other bacteriostatic drugs may interfere w/ bactericidal effect.
MIMS Class
ATC Classification
J01CA04 - amoxicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Presentation/Packing
Form
Apo-Amoxi cap 250 mg
Packing/Price
1000's
Form
Apo-Amoxi oral susp 250 mg/5 mL
Packing/Price
100 mL x 1's
Form
Apo-Amoxi oral susp 125 mg/5 mL
Packing/Price
150 mL x 1's
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