Concise Prescribing Info
Edema associated w/ CHF, liver cirrhosis, nephrosis & chronic nephritis, & other edematous states amenable to diuretic therapy. Monotherapy in the control of mild to moderate HTN &/or in combination w/ other antihypertensives in more severe cases.
Dosage/Direction for Use
Edema Adult Initially 40-80 mg. If diuresis has not occurred after 6 hrs, increase dosage by increments of 40 mg every 6 hr if necessary. May be repeated 1-3 times daily. Max daily dose: 200 mg. An intermittent dosage schedule of 2-4 consecutive days each wk may be utilized. Childn Single oral dose of 0.5-1 mg/kg. Max daily dose: 2 mg/kg in divided doses 6-12 hrly. An intermittent dosage schedule should be adopted as soon as possible using the min effective dose at the longest possible intervals. Newborn & premature baby Max daily dose: 1 mg/kg. HTN Adult 40-80 mg daily.
Should be taken on an empty stomach: If GI distress occurs, take w/ food or milk.
Hypersensitivity. Increasing azotemia & oliguria occur during treatment of progressive renal disease. Hepatic coma & states of electrolyte depletion. Jaundiced newborn infants or infants w/ potential of causing hyperbilirubinemia & kernicterus.
Special Precautions
Hypersensitivity to other antibacterial, diuretic, or hypoglycemic sulfonamide derivatives. Discontinue furosemide for 1 wk prior to elective surgery. Dehydration & reduction of blood vol w/ circulatory collapse & possibility of  vascular thrombosis & embolism particularly in elderly. Frequent serum electrolyte, CO2 & BUN determinations should be performed during the 1st few mth of therapy & periodically thereafter. Hospitalize patients w/ hepatic cirrhosis & ascites prior to initiating therapy. Observe for possible occurrence of blood dyscrasias, liver damage or idiosyncratic reactions. K supplements may be required especially when high doses are used over prolonged periods. Obtain periodic serum Ca levels. Avoid concomitant administration w/ cephaloridine. Do not use in women of childbearing potential & during pregnancy.
Adverse Reactions
Excessive diuresis &/or electrolyte depletion; reversible deafness & tinnitus; asymptomatic hyperuricemia; various forms of dermatitis (including urticaria); anemia, leukopenia, aplastic anemia & thrombocytopenia (w/ purpura).
Drug Interactions
Do not administer w/ acetazolamide, carbenoxolone, corticosteroids, corticotrophin & indapamide. Concurrent w/ amiodarone, disopyramide, flecainide & quinidine may increase toxicity w/ hypokalaemia. Caution w/ sotalol, prenylamine, lidoflazine or lignocaine.
MIMS Class
ATC Classification
C03CA01 - furosemide ; Belongs to the class of high-ceiling sulfonamide diuretics.
Apo-Furosemide tab 40 mg
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