Hypersensitivity to other antibacterial, diuretic, or hypoglycemic sulfonamide derivatives. Discontinue furosemide for 1 wk prior to elective surgery. Dehydration & reduction of blood vol w/ circulatory collapse & possibility of vascular thrombosis & embolism particularly in elderly. Frequent serum electrolyte, CO2
& BUN determinations should be performed during the 1st few mth of therapy & periodically thereafter. Hospitalize patients w/ hepatic cirrhosis & ascites prior to initiating therapy. Observe for possible occurrence of blood dyscrasias, liver damage or idiosyncratic reactions. K supplements may be required especially when high doses are used over prolonged periods. Obtain periodic serum Ca levels. Avoid concomitant administration w/ cephaloridine. Do not use in women of childbearing potential & during pregnancy.