Full Prescribing Info
Each tablet contains hydrochlorothiazide 25 mg or 50 mg, respectively.
Pharmacotherapeutic Group: Diuretics-Antihypertensive.
Pharmacology: Hydrochlorthiazides inhibits reabsorption of sodium and chloride in the distal tubules thus promoting water loss. Although a mild diuretics, its combination with a loop diuretics is particularly potent because the latter present much more sodium chloride to the distal tubules.
Oedema, hypertension.
Dosage/Direction for Use
Oedema: initially 50-100 mg daily, maintenance 25-50 mg on alternative days.
Hypertension: 25 mg daily, can be increased to 50-100 mg daily if necessary.
Anuria: discontinue if increasing azotemia and oliguria occur during treatment of severe progressive renal disease or renal failure. Do not use in patients known to be sensitive to thiazides or other sulfonamide derived drugs.
Use In Pregnancy & Lactation
The routine use of thiazide diuretics in an otherwise healthy woman with or without oedema is contraindicated. Thiazides cross the placental barrier and may carry a similar risk to the foetus of experiencing adverse effects such as jaundice, thrombocytopenia. Thiazides are excreted into the milk of the nursing mother although apparently not in significant amounts.
Adverse Reactions
Gastrointestinal: anorexia, gastric irritation, nausea, vomiting, cramping, diarrhea, dryness of mouth or increased thirst.
CNS: dizziness, vertigo, mood or mental changes.
Hypersensitivity: photosensitivity, rash, urticaria, sore throat and fever, thrombocytopenia.
Miscellaneous: muscle spasm, weakness, tiredness, joint pain, irregular heartbeats.
Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced of therapy withdrawn.
Drug Interactions
Concurrent use of Lithium with thiazide diuretics is not recommended as they may provoke lithium toxicity because of reduced renal clearance. Concurrent use of Methenamine and thiazide diuretics is not recommended because of the possibility that the urine will become alkaline, thereby reducing the effectiveness of methanamine by inhibiting its conversion to formaldehyde.
Caution For Usage
Incompatibilities: Concurrent use of thiazide diuretics with food containing large dose of calcium or other calcium containing medication may cause hypercalcemia because of reduced calcium excretion.
Caution is recommended when topical or systemic photosensitizing medication is used concurrent with thiazide diuretics because of possible active photosensitive effects.
Store below 40 degrees C, preferably between 15 and 30 degrees C. Store in a tight container.
MIMS Class
ATC Classification
C03AA03 - hydrochlorothiazide ; Belongs to the class of low-ceiling thiazide diuretics.
Tab 25 mg x 1,000's. 50 mg x 1,000's.
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