Apo-ISDN Adverse Reactions

isosorbide dinitrate




Full Prescribing Info
Adverse Reactions
Headache is the most frequent adverse effect, and it may be severe and persistant. This occurs most frequently at the beginning of therapy. Usually a temporary reduction in dosage will control headache along with a concomitant administration of commonly used analgesics, or by administering the drug during meals. These headaches disappear within a week of continuous, uninterrupted therapy. Advise the patient they may occur and that isosorbide is important with regard to preventing of angina. Occasionally, drug and/or exfoliative dermatitis occur. Signs of cerebral ischemia associated with postural hypotension, such as weakness and transient episodes of dizziness, may occasionally develop. Cutaneous vasodilation with flushing may occur. Rarely, a marked sensitivity to the hypotensive effects of the drug can occur with a severe response (nausea, vomiting, restlessness, perspiration, and collapse); alcohol may enhance this effect. Isosorbide can antagonize the effects of histamine, acetylcholine, and similar agents.
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