The data supporting the use of nitrates during the early days of the acute phase of myocardial infarction (the period during which clinical and laboratory findings are unstable) are not sufficient to establish safety.
Nitrate dependence may occur with chronic use. To avoid possible withdrawal effects, gradually reduce administration. Do not discontinue abruptly. Chest pain, acute myocardial infarction, and even sudden death have occurred during a temporary withdrawal of nitrate exposure in industry workers continuously exposed to nitrates.