Symptoms: Ingestion of 120 mg (60 tablets) of prazosin in a 72 year old man resulted in profound drowsiness, severely depressed blood pressure and minimally elevated heart rate. After appropriate remedial measures were taken, recovery was uneventful.
Treatment: Should overdosage lead to hypotension, support of the cardiovascular system is of first importance. Restoration or blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If necessary, vasopressors should be used. If this measure is inadequate, shock should then be treated with volume expanders. Renal function should be monitored and supported as needed. Laboratory data indicate that prazosin is not dialyzable because it is protein bound.