Symptoms of depression including depression accompanied by symptoms of anxiety in patients w/ or w/o history of mania, obsessive-compulsive disorder (OCD), panic disorder (w/ or w/o agoraphobia), post-traumatic stress disorder (PTSD).
Depression & OCD Initially 50 mg/day. Panic disorder & PTSD Initially 25 mg/day. After 1 wk, dose should be increased to 50 mg once daily. Titration: If necessary, increase dose at intervals of at least 1 wk to a max of 200 mg/day.
Switching from selective serotonin re-uptake inhibitors, antidepressants or antiobsessional drugs. History of mania/hypomania, seizure disorder. Suicidal tendencies. Hepatic impairment. May affect ability to drive or operate machinery. Pregnancy & lactation.