Apo-Theo LA

Apo-Theo LA

theophylline

Manufacturer:

Apotex

Distributor:

Pharmaforte
Concise Prescribing Info
Contents
Anhydrous theophylline
Indications/Uses
Symptomatic treatment of reversible bronchospasm associated w/ asthma, chronic bronchitis, emphysema & related bronchospastic disorders.
Dosage/Direction for Use
Adult Initially 200-300 mg every 12 hr, may be increased by 50-100 mg every 12 hr at 3-day intervals until a satisfactory response is obtained or toxic effects appear. Max: 16 mg/kg daily.
Administration
Should be taken with food: Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity to theophylline or xanthine derivatives. Peptic ulcer, CAD.
Special Precautions
Not suitable for immediate bronchodilatation. Reassess in patients showing intolerance. May cause peripheral vascular collapse. Patients >55 yr particularly males & w/ chronic lung disease; cardiac failure from any cause. Concomitant use w/ macrolides & cimetidine; influenza immunization or active infection w/ influenza; other theophylline derivatives. Severe cardiac disease, severe hypoxemia, HTN, hyperthyroidism, acute myocardial injury, cor pulmonale, CHF, liver disease. History of peptic ulcer. May cause elevation of urine catecholamines & plasma fatty acids in interpretation of biochemistry test. Falsely high values in spectrophotometric methods when given w/ coffee, tea, cola beverages, chocolate & acetaminophen; in high pressure liquid chromatography method when given w/ caffeine, some cephalosporin & sulfa medications. Smokers. Renal & hepatic impairment. Pregnancy & lactation. Not recommended in childn <12 yr. Elderly (especially males).
Adverse Reactions
Nausea, vomiting, epigastric pain, headache, tremor. W/ high doses, cardiac arrhythmias or seizures may occur.
Drug Interactions
Increased t½ & decreased clearance w/ cimetidine, propranolol, allopurinol, macrolide antibiotics (erythromycin), OCs, alkalinizing agents, influenza vaccine. Decreased t½ & increased clearance w/ phenytoin, barbiturates, carbamazepine, isoproterenol, rifampin, smoking (tobacco), acidifying agents. Increased cardiac effect of digitalis glycosides; diuresis of thiazides; nephrotoxicity of nephrotoxic drugs. Increased ratio of lithium/CrCl, thus decreased serum lithium. Increased toxicity & CNS stimulation of sympathomimetic amines. Decreased anticoagulant activity, increased prothrombin & fibrinogen blood conc, shorten prothrombin time of coumarin anticoagulants. Decreased antihyperuricemic action of allopurinol; uricosuric action of probenecid & pyrazolon derivatives; threshold value for inducing convulsions of ketamine.
ATC Classification
R03DA04 - theophylline ; Belongs to the class of xanthines. Used in the systemic treatment of obstructive airway diseases.
Presentation/Packing
Form
Apo-Theo LA SR tab 100 mg
Packing/Price
100's
Form
Apo-Theo LA SR tab 200 mg
Packing/Price
100's
Form
Apo-Theo LA SR tab 300 mg
Packing/Price
100's
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