Exaggerated succinylcholine-type muscle relaxation during anaesth. Vagotonic effects on SA & AV nodes; syncopal episodes. May cause diarrhea, nausea, vomiting, wt loss. Patients w/ increased risk for developing ulcers eg, history of ulcer disease & those receiving concurrent NSAIDs. May cause bladder outflow obstruction. May exacerbate or induce extrapyramidal symptoms. History of asthma or obstructive pulmonary disease. Avoid concomitant use w/ other inhibitors of acetylcholinesterase, cholinergic system agonists or antagonists. Discontinue therapy if signs & symptoms of neuroleptic malignant syndrome or presents w/ unexplained high fever develop. Patients w/ predisposing/risk factors eg, prior history of muscular disorders, uncontrolled hypothyroidism, hepatic or renal impairment. Concomitant use w/ rhabdomyolysis-causing medications (eg, statins, antipsychotics, SSRIs/SNRIs). Dementia may affect ability to drive or operate machinery. Not recommended for childn.