Axetine

Axetine

cefuroxime

Manufacturer:

Medochemie

Distributor:

Medochemie
Concise Prescribing Info
Contents
Cefuroxime axetil
Indications/Uses
Treatment of upper & lower resp tract, GUT, skin & soft tissue infections; gonorrhoea, acute uncomplicated gonococcal urethritis & cervicitis.
Dosage/Direction for Use
Usual course of therapy: 7 days (range of 5-10 days). Adult Most infections 250 mg bd. UTI 125 mg bd. Mild to moderate lower resp tract infections eg, bronchitis 250 mg bd. More severe lower resp tract infections or if pneumonia is suspected 500 mg bd. Pyelonephritis 250 mg bd. Uncomplicated gonorrhoea 1 g as single dose. Sequential therapy: Pneumonia Cefuroxime 1.5 g bd-tds (IV/IM) for 48-72 hr, followed by Axetine 500 mg bd orally for 7-10 days. Acute exacerbations of chronic bronchitis Cefuroxime 750 mg bd-tds (IV/IM) for 48-72 hr, followed by Axetine 500 mg bd orally 5-10 days. Childn Most infections 125 mg bd up to a max of 250 mg daily. Childn ≥2 yr w/ otitis media or more severe infections 250 mg bd up to a max of 500 mg daily.
Administration
Should be taken with food: Take w/ meals for optimum absorption.
Contraindications
Hypersensitivity to cefuroxime & other cephalosporins.
Special Precautions
Patients w/ previous allergic reaction to penicillins or other β-lactams. Prolonged use. Pseudomembranous colitis. May affect ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
Overgrowth of Candida; eosinophilia; headache, dizziness; GI disturbances (including diarrhoea, nausea, abdominal pain); transient increases of hepatic enzyme levels.
Drug Interactions
Decreased bioavailability w/ drugs which reduce gastric acidity. May affect gut flora leading to lower oestrogen reabsorption & reduced efficacy of combined OCs.
MIMS Class
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Axetine tab 500 mg
Packing/Price
1 × 10's
Form
Axetine tab 250 mg
Packing/Price
1 × 10's
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