The usual course of therapy is seven days (range 5-10 days).
Adults: Most Infections: 250 mg twice daily. Urinary Tract Infections: 125 mg twice daily. Mild to Moderate Lower Respiratory Tract Infections eg, Bronchitis: 250 mg twice daily. More Severe Lower Respiratory Tract Infections, or if Pneumonia is Suspected: 500 mg twice daily. Pyelonephritis: 250 mg twice daily. Uncomplicated Gonorhhoea: Single dose of 1g.
Sequential Therapy: Pneumonia: 1.5 g, 2 or 3 times a day (IV or IM) for 48-72 hrs, followed by 500 mg twice daily Axetine oral therapy for 7-10 days.
Acute Exacerbations of Chronic Bronchitis: 750 mg, 2 or 3 times a day (IV or IM) for 48-72 hrs, followed by 500 mg twice daily Axetine oral therapy for 5-10 days.
Duration of both parenteral and oral therapy is determined by the severity of the infection and the clinical status of the patient.
Children: Most Infections: 125 mg twice daily, to a maximum of 250 mg daily. ≥2 years: Otitis Media or, where Appropriate, with More Severe Infections: 250 mg (one 250 mg tablet or two 125 mg tablets) twice daily, to a maximum of 500 mg daily.
Administration: Cefuroxime axetil should be taken after food for optimum absorption.
Axetine tablets should not be crushed and are therefore unsuitable for treatment of patients eg, younger children, who cannot swallow tablets. In children cefuroxime oral suspension may be used.