Azatadine


Generic Medicine Info
Indications and Dosage
Oral
Allergic conditions
Adult: 1 mg bid increased to 2 mg bid if needed.
Child: 6-12 yr: 0.5-1 mg bid.
Administration
May be taken with or without food. May be taken w/ food or milk if stomach upset occurs.
Contraindications
Neonates; patients receiving MAOI therapy; lactation.
Special Precautions
Angle-closure glaucoma, increased intraocular pressure, stenosing peptic ulcer, pyloroduodenal obstruction, epilepsy; renal and hepatic impairment. May impair ability to drive or operate machinery; pregnancy.
Adverse Reactions
Drowsiness, dizziness, headache, fatigue, nervousness; anticholinergic effects, thick bronchial secretions; arthralgia; pharyngitis; increased appetite, wt gain, nausea, diarrhoea, abdominal pain, dry mouth; impaired alertness.
Drug Interactions
Potentiates CNS depression with other CNS depressants e.g. TCAs, procarbazine and alcohol.
Potentially Fatal: MAOIs enhance anticholinergic side effect of azatadine. Enhance depressant action of anxiolytic and sedating drugs.
Food Interaction
Alcohol may enhance sedative effects.
Action
Description: Azatadine has anticholinergic and antiserotonin activity. It inhibits mediator release from mast cells by preventing calcium entry through voltage-dependent calcium channels.
Pharmacokinetics:
Absorption: Absorbed from the GI tract (oral); peak plasma concentrations after 4 hr.
Metabolism: Minimal metabolism.
Excretion: Via the urine (as unchanged drug and metabolites); 9-12 hr (elimination half-life).
Storage
Store at 2-30°C.
Disclaimer: This information is independently developed by MIMS based on Azatadine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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