Benzoyl peroxide: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the local prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Acne

Adult: As 2.5-10% preparation: Apply 1-2 times daily after cleansing, may gradually increase to tid if needed. Start w/ lower strength preparations. As cleanser: Wash 1-2 times daily.
Child: ≥12 yr Same as adult dose.

Topical/Cutaneous
Decubitus/stasis ulcers

Adult: As 20% lotion: Apply 8-12 hrly.

Contraindications

Hypersensitivity.

Special Precautions

Childn. Pregnancy and lactation.

Adverse Reactions

Dry skin, erythema, skin exfoliation and burning sensation, pruritus, irritation, allergic contact dermatitis, swelling face.
Potentially Fatal: Rarely, hypersensitivity reactions.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Avoid unnecessary sun exposure. May cause discolouration of hair and dyed fabrics.

MonitoringParameters

Perform sensitivity test before using the product for the 1st time.

Overdosage

Symptom: Severe irritation: Management: Symptomatic treatment.

Drug Interactions

Decreased efficacy and increase irritation if concomitantly administered w/ tretinoin, isotretinoin and tazarotene. Temporary skin and facial hair discolouration (yellow/orange) w/ sulphonamide-containing products.

Action

Description: Benzoyl peroxide has mild keratolytic effect and antimicrobial activity due to release of free-radical oxygen which oxidizes bacterial protein. It is active against Staphylococcus epidermidis and Propionibacterium acnes.
Pharmacokinetics:
Absorption: Approx 5% is absorbed through the skin.
Metabolism: Metabolised in the skin to benzoic acid.
Excretion: Via urine.

Chemical Structure

Storage

Store between 15-30˚C.

MIMS Class

Acne Treatment Preparations

ATC Classification

D10AE01 - benzoyl peroxide ; Belongs to the class of topical peroxide preparations used in the treatment of acne.

References

Anon. Benzoyl Peroxide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/06/2016.

Benzoyl Peroxide 10% Gel (Axia Medical Solutions, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/06/2016.

Buckingham R (ed). Benzoyl Peroxide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/06/2016.

Joint Formulary Committee. Benzoyl Peroxide. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/06/2016.

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