Pharmacology: Pharmacodynamics: Betamethasone dipropionate is a topically active fluorinated corticosteroid which has anti-inflammatory, antipruritic and vasoconstrictive actions. Gentamicin sulphate is a broad spectrum aminoglycoside antibiotic which is bactericidal. It is effective against many strains of gram-negative bacteria and Staphylococcus aureus.
Pharmacokinetics: Corticosteroids are extensively bound to plasma protein. Only unbound corticosteroids has pharmacological effects or is metabolised.
They are metabolised mainly in the liver and also in the kidney, and are excreted in the urine.
Gentamicin sulphate is a bactericidal antibiotic which is active against a wide variety of pathogenic gram-positive and gram-negative bacteria. When applied topically to large areas of denuded body surface as the case of burn patients, plasma concentrations can reach 1mcg/ml, and 2% of the drug used may appear in the urine.