Regular monitoring of liver enzymes in patients w/ severe liver impairment. Discontinue use in case of a rise of the liver enzymes during treatment, particularly on long-term use. Assess increased risk to develop GI complications according to individual risk factors eg, high age (>65 yr), history of gastric or duodenal ulcer or upper GI bleeding. Presence of any alarm symptoms (eg, significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis, anemia or malaena) & in present or suspected gastric ulcer. May reduce the absorption of vit B12
due to hypo- or achlorhydria on long-term therapy. Use the lowest dose & shortest duration of therapy appropriate in Clostridium difficile
-associated diarrhoea; bone fracture. Monitor Mg levels prior to initiation of treatment & periodically. Concomitant use w/ methotrexate &/or its metabolite. Not to be used during pregnancy & lactation. Childn. 40-mg: Do not use for mild GI complaints eg, nervous dyspepsia. Not to be used in childn.